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Rhodium-Catalyzed Generation of Anhydrous Hydrogen Iodide: An Effective Method for the Preparation of Iodoalkanes

Chaoyuan Zeng, Guoli Shen, Fan Yang, Jingchao Chen*, Xuexin Zhang, Cuiping Gu, Yongyun Zhou, Baomin Fan*

*YMU-HKBU Joint Laboratory of Traditional Natural Medicine, Yunnan Minzu University, Kunming 650500, China, Email:,

C. Zeng, G. Shen, F. Yang, J. Chen, X. Zhang, C. Gu, Y. Zhou, B. Fan, Org. Lett., 2018, 20, 6859-6862.

DOI: 10.1021/acs.orglett.8b02980

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Anhydrous hydrogen iodide preparated directly from molecular hydrogen and iodine using a rhodium catalyst is highly active in the transformations of alkenes, phenyl aldehydes, alcohols, and cyclic ethers to the corresponding iodoalkanes. Therefore, the present methodology offers a practical method for the preparation of various iodoalkanes in excellent atom economy.

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Key Words

benzyl iodides, alkyl iodides, hydrogen

ID: J54-Y2018