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Catalyst-Free Decarboxylative Fluorination of Tertiary β-Keto Carboxylic Acids

Misaki Katada, Kazumasa Kitahara, Seiji Iwasa, Kazutaka Shibatomi*

*Department of Environmental and Life Sciences, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi 441-8580, Japan, Email:

M. Katada, K. Kitahara, S. Iwasa, K. Shibatomi, Synlett, 2018, 29, 2408-2411.

DOI: 10.1055/s-0037-1611019 (free Supporting Information)


A decarboxylative fluorination of tertiary β-keto carboxylic acids using an electrophilic fluorinating reagent proceeded in the absence of a catalyst or base to yield the corresponding α-fluoroketones very good yields.

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Key Words

fluorination, decarboxylation, α-fluoroketones, tertiary fluorides, Selectfluor

ID: J72-Y2018