Catalyst-Free Decarboxylative Fluorination of Tertiary β-Keto Carboxylic Acids
Misaki Katada, Kazumasa Kitahara, Seiji Iwasa, Kazutaka Shibatomi*
*Department of Environmental and Life Sciences, Toyohashi
University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi 441-8580,
Japan, Email: shiba
ens.tut.ac.jp
M. Katada, K. Kitahara, S. Iwasa, K. Shibatomi, Synlett, 2018, 29, 2408-2411.
Abstract
A decarboxylative fluorination of tertiary β-keto carboxylic acids using an electrophilic fluorinating reagent proceeded in the absence of a catalyst or base to yield the corresponding α-fluoroketones very good yields.
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Key Words
fluorination, decarboxylation, α-fluoroketones, tertiary fluorides, Selectfluor
ID: J72-Y2018
