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Application of Hantzsch Ester and Meyer Nitrile in Radical Alkynylation Reactions

Xu Liu, Ruoyu Liu, Jie Dai, Xu Cheng*, Guigen Li

*Institute of Chemistry and Biomedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China, Email:

X. Liu, R. Liu, J. Dai, X. Cheng, G. Li, Org. Lett., 2018, 20, 6906-6909.

DOI: 10.1021/acs.orglett.8b03050


A coupling of substituted Hantzsch esters or Meyer nitriles with benziodoxole-activated alkynes provides products containing Csp3-Csp bonds involving primary, secondary, and tertiary carbon centers in good yields. K2S2O8 was the optimum radical initiator in this reaction.

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Key Words

alkynylation, potassium peroxydisulfate

ID: J54-Y2018