Cooperative Palladium/Lewis Acid-Catalyzed Transfer Hydrocyanation of Alkenes and Alkynes Using 1-Methylcyclohexa-2,5-diene-1-carbonitrile
Anup Bhunia, Klaus Bergander, Armido Studer*
*Organisch-Chemisches Institut, Westfalische Wilhelms-Universität, Corrensstraβe 40, 48149 Münster, Germany,
Email: studer
uni-muenster.de
A. Bhunia, K. Bergander, A. Studer, J. Am. Chem. Soc., 2018, 140, 15976-15984.
DOI: 10.1021/jacs.8b10651
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Abstract
Transfer hydrocyanation represents a clean and safe alternative to hydrocyanation processes using toxic HCN gas. An efficient and practical cooperative palladium/Lewis acid-catalyzed transfer hydrocyanation of alkenes and alkynes with 1-methylcyclohexa-2,5-diene-1-carbonitrile as a benign and readily available HCN source provides a large set of nitrile derivatives with good to excellent anti-Markovnikov selectivity.
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Key Words
ID: J48-Y2018
