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Cooperative Palladium/Lewis Acid-Catalyzed Transfer Hydrocyanation of Alkenes and Alkynes Using 1-Methylcyclohexa-2,5-diene-1-carbonitrile

Anup Bhunia, Klaus Bergander, Armido Studer*

*Organisch-Chemisches Institut, Westfalische Wilhelms-Universität, Corrensstraβe 40, 48149 Münster, Germany, Email:

A. Bhunia, K. Bergander, A. Studer, J. Am. Chem. Soc., 2018, 140, 15976-15984.

DOI: 10.1021/jacs.8b10651

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Transfer hydrocyanation represents a clean and safe alternative to hydrocyanation processes using toxic HCN gas. An efficient and practical cooperative palladium/Lewis acid-catalyzed transfer hydrocyanation of alkenes and alkynes with 1-methylcyclohexa-2,5-diene-1-carbonitrile as a benign and readily available HCN source provides a large set of nitrile derivatives with good to excellent anti-Markovnikov selectivity.

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Key Words


ID: J48-Y2018