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Palladium-Catalyzed Three-Component Reaction: A Novel Method for the Synthesis of N-Acyl Propiolamides

Yan He, Yingchun Wang, Xinping Liang, Bin Huang, Hengshan Wang*, Ying-Ming Pan*

*School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, People's Republic of China, Email:,

Y. He, Y. Wang, X. Liang, B. Huang, H. Wang, Y.-M. Pan, Org. Lett., 2018, 20, 7117-7120.

DOI: 10.1021/acs.orglett.8b03068

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An operationally simple, palladium-catalyzed three-component reaction between terminal alkynes, isonitriles, and sodium carboxylates provides N-acyl propiolamide derivatives under mild conditions.

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Key Words

propiolamides, hydrolysis, multicomponent reactions

ID: J54-Y2018