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Base-Mediated Direct Transformation of N-Propargylamines into 2,3,5-Trisubstituted 1H-Pyrroles

Pawan K. Mishra, Shalini Verma, Manoj Kumar, Akhilesh K. Verma*

*Department of Chemistry, University of Delhi, Delhi 110007, India, Email:

P. K. Mishra, S. Verma, M. Kumar, A. K. Verma, Org. Lett., 2018, 20, 7182-7185.

DOI: 10.1021/acs.orglett.8b03112 (free Supporting Information)


An efficient and base-mediated intramolecular cyclization of N-propargylamines provides structurally diversified pyrroles in high yield. The method is broadly applicable and tolerates various functional groups.

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ID: J54-Y2018