Eosin Y- and Copper-Catalyzed Dark Reaction To Construct Ene-γ-Lactams
Wen-Long Lei, Kai-Wen Feng, Tao Wang, Li-Zhu Wu, Qiang Liu*
*State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China,
Email: liuqiang
lzu.edu.cn
W.-L. Lei, K.-W. Feng, T. Wang, L.-Z. Wu, Q. Liu, Org. Lett., 2018, 20, 7220-7224.
DOI: 10.1021/acs.orglett.8b03147
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Abstract
The common organo-photocatalyst Eosin Y shows excellent catalytic activities for thermal redox reactions under a catalytic amount of Cu(OAc)2 too. Using this catalytic system, a formal [3 + 2] cycloaddition of vinyl azides and ketene silyl acetals provides five-membered ene-γ-lactams and bridge ring lactams via an α-ester radical addition without light irradiation.
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Key Words
ID: J54-Y2018
