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Nickel-Catalyzed Cyanation of Phenol Derivatives with Zn(CN)2 Involving C-O Bond Cleavage

Yi Gan, Gaonan Wang, Xin Xie, Yuanhong Liu*

*Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, People's Republic of China, Email: yhliusioc.ac.cn

Y. Gan, G. Wang, X. Xie, Y. Liu, J. Org. Chem., 2018, 83, 14036-14048.

DOI: 10.1021/acs.joc.8b02498 (free Supporting Information)



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Abstract

An efficient nickel(II)-catalyzed cyanation of aryl sulfonates, fluorosulfonates, and sulfamates with Zn(CN)2 provides nitrile products in very good yields in the presence of DMAP as the additive. The method offers wide functional group compatibility.

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Key Words

cyanation


ID: J42-Y2018