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Synthesis of Indoles via Electron-Catalyzed Intramolecular C-N Bond Formation

Dmitry I. Bugaenko, Anastasia A. Dubrovina, Marina A. Yurovskaya, Alexander V. Karchava*

*Department of Chemistry, Moscow State University, Moscow 119234, Russia, Email: karchavaorg.chem.msu.ru

D. I. Bugaenko, A. A. Dubrovina, M. A. Yurovskaya, A. V. Karchava, Org. Lett., 2018, 20, 7358-7362.

DOI: 10.1021/acs.orglett.8b02784 (free Supporting Information)


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Abstract

A t-BuOK/DMF system without special initiators or additives enables the preparation of N-substituted indole-3-carboxylates in high yields under transition-metal-free conditions. These conditions are particularly attractive for manufacturing halogenated indoles.

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Key Words

indoles


ID: J54-Y2018