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Palladium-Catalyzed Chemoselective Protodecarboxylation of Polyenoic Acids

Mohammed H. Al-Huniti, Mark A. Perez, Matthew K. Garr, Mitchell P. Croatt*

*Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, 435 Sullivan Science Building, Greensboro, North Carolina 27402, United States, Email: mpcroattuncg.edu

M. H. Al-Huniti, M. A. Perez, M. K. Garr, M. P. Croatt, Org. Lett., 2018, 20, 7392-7395.

DOI: 10.1021/acs.orglett.8b03016 (free Supporting Information)


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Abstract

A palladium-catalyzed chemoselective protodecarboxylation of polyenoic acids provides the desired polyenes in good yields under mild conditions using either a Pd(0) or Pd(II) catalyst. The reaction tolerates a variety of aryl and aliphatic substitutions.

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Key Words

decarboxylation, 1,3-dienes


ID: J54-Y2018