Electrochemical Oxidation with Lewis-Acid Catalysis Leads to Trifluoromethylative Difunctionalization of Alkenes Using CF3SO2Na
Lingling Zhang, Guoting Zhang, Pan Wang, Yongli Li, Aiwen Lei*
*The Institute for Advanced Studies (IAS), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, People's Republic of China, Email: aiwenleiwhu.edu.cn
L. Zhang, G. Zhang, P. Wang, Y. Li, A. Lei, Org. Lett., 2018, 20, 7396-7399.
DOI: 10.1021/acs.orglett.8b03081 (free Supporting Information)
see article for more reactions
A constant current electrolysis synergizing with a Lewis-acid catalysis protocol enables an external oxidant-free oxytrifluoromethylation and aminotrifluoromethylation of styrene derivatives using sodium trifluoromethanesulfinate as the trifluoromethyl source.
see article for more examples