Electrochemical Oxidation with Lewis-Acid Catalysis Leads to Trifluoromethylative Difunctionalization of Alkenes Using CF₃SO₂Na

Lingling Zhang, Guoting Zhang, Pan Wang, Yongli Li, Aiwen Lei*

*The Institute for Advanced Studies (IAS), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, People's Republic of China, Email: aiwenleiwhu.edu.cn

L. Zhang, G. Zhang, P. Wang, Y. Li, A. Lei, Org. Lett., 2018, 20, 7396-7399.

DOI: 10.1021/acs.orglett.8b03081

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Abstract

A constant current electrolysis synergizing with a Lewis-acid catalysis protocol enables an external oxidant-free oxytrifluoromethylation and aminotrifluoromethylation of styrene derivatives using sodium trifluoromethanesulfinate as the trifluoromethyl source.

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Key Words

trifluormethylation, β-trifluoromethyl alcohols, ethers, electrochemistry, multicomponent reactions

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ID: J54-Y2018