Organic Chemistry Portal

Abstracts

Search:

Base-Controlled Three Component Reactions of Amines, Elemental Sulfur, and Styrenes: Synthesis of Thioamides under Metal-Free Conditions

Pingshun Zhang, Wanzhi Chen*, Miaochang Liu, Huayue Wu*

*Department of Chemistry, Zhejiang University, Yuquan Campus, Hangzhou 310007; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China, Email: chenwzzzju.edu.cn, hywu3163.com

P. Zhang, W. Chen, M. Liu, H. Wu, J. Org. Chem., 2018, 83, 14269-14276.

DOI: 10.1021/acs.joc.8b01721 (free Supporting Information)


see article for more reactions

Abstract

Base-controlled three component reactions of styrenes, amines, and sulfur provide thioamides. Depending on the base, 2-phenylethanethioamides and benzothioamides were obtained selectively.


see article for more examples



Key Words

thioamides (thionation, amination), multicomponent reactions


ID: J42-Y2018