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Palladium-Catalyzed Reductive Coupling of Nitroarenes with Phenols­ leading to N-Cyclohexylanilines

Kai-Jian Liu, Xiu-Ling Zeng, Yong Zhang, Yi Wang, Xin-Sheng Xiao, Huilan Yue, Ming Wang, Zilong Tang, Wei-Min He*

*Hunan Provincial Engineering Research Center for Ginkgo biloba, Hunan University of Science and Engineering, Yongzhou 425100, P. R. of China, Email: weiminhe2016yeah.net

K.-J. Liu, X.-L. Zeng, Y. Zhang, Y. Wang, X.-S. Xiao, H. Yue, M. Wang, Z. Tang, W.-M. He, Synthesis, 2018, 50, 4637-4644.

DOI: 10.1055/s-0037-1610231 (free Supporting Information)


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Abstract

A direct and efficient palladium-catalyzed reductive coupling of nitroarenes with phenols provides various N-cyclohexylaniline derivatives in good yields using safe and inexpensive sodium formate as the hydrogen donor.

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Key Words

green chemistry, palladium catalysis, reductive coupling, sodium formate, nitroarenes, phenol, cyclohexylamines, amines


ID: J66-Y2018