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Visible-Light-Promoted C-S Cross-Coupling via Intermolecular Charge Transfer

Bin Liu, Chern-Hooi Lim, Garret M. Miyake*

*Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States, Email: garret.miyakecolostate.edu

B. Liu, C. H. Lim, G. M. Miyake, J. Am. Chem. Soc., 2017, 139, 13616-13619.

DOI: 10.1021/jacs.7b07390 (free Supporting Information)


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Abstract

A mild, scalable, visible-light-promoted cross-coupling reaction between thiols and aryl halides provides various aryl thioethers in the absence of both transition metal and photoredox catalysts. This C-S coupling protocol was also applied in late-stage modifications of active pharmaceutical ingredients.


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Key Words

diaryl sulfides, photochemistry


ID: J48-Y2018