Organic Chemistry Portal



Visible-Light-Promoted C-S Cross-Coupling via Intermolecular Charge Transfer

Bin Liu, Chern-Hooi Lim, Garret M. Miyake*

*Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States, Email:

B. Liu, C. H. Lim, G. M. Miyake, J. Am. Chem. Soc., 2017, 139, 13616-13619.

DOI: 10.1021/jacs.7b07390

see article for more reactions


A mild, scalable, visible-light-promoted cross-coupling reaction between thiols and aryl halides provides various aryl thioethers in the absence of both transition metal and photoredox catalysts. This C-S coupling protocol was also applied in late-stage modifications of active pharmaceutical ingredients.

see article for more examples

Key Words

diaryl sulfides, photochemistry

ID: J48-Y2018