Organic Chemistry Portal



Visible-Light-Driven External-Reductant-Free Cross-Electrophile Couplings of Tetraalkyl Ammonium Salts

Li-Li Liao, Guang-Mei Cao, Jian-Heng Ye, Guo-Quan Sun, Wen-Jun Zhou, Yong-Yuan Gui, Si-Shun Yan, Guo Shen, Da-Gang Yu*

*Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, People's Republic of China, Email:

L.-L. Liao, G.-M. Cao, J.-H. Ye, G.-Q. Sun, W.-J. Zhou, Y.-Y. Gui, S.-S. Yan, G. Shen, D.-G. Yu, J. Am. Chem. Soc., 2018, 140, 17338-17342.

DOI: 10.1021/jacs.8b08792

see article for more reactions


Visible-light photoredox catalysis realizes an external-reductant-free cross-electrophile coupling of tetraalkyl ammonium salts with carbonyl compounds and CO2. The byproduct trimethylamine serves as the electron donor. Moreover, this protocol exhibits mild reaction conditions, broad substrate scope, good functional group tolerance, low catalyst loading, and facile scalability.

see article for more examples

Key Words

carboxylation, benzylation, photochemistry

ID: J48-Y2018