Direct Catalytic Enantioselective Benzylation from Aryl Acetic Acids
Patrick J. Moon, Zhongyu Wei, Rylan J. Lundgren*
*Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada, Email: rylan.lundgrenualberta.ca
P. J. Moon, Z. Wei, R. J. Lundgren, J. Am. Chem. Soc., 2018, 140, 17418-17422.
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An Ir-catalyzed enantioselective benzylation reaction of allylic electrophiles can occur directly from aryl acetic acids via stereoselective carbon-carbon bond formation followed by decarboxylation as the terminal event. The absence of a highly basic nucleophile enables broad functional group compatibility.
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