Organic Chemistry Portal



Direct Catalytic Enantioselective Benzylation from Aryl Acetic Acids

Patrick J. Moon, Zhongyu Wei, Rylan J. Lundgren*

*Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada, Email:

P. J. Moon, Z. Wei, R. J. Lundgren, J. Am. Chem. Soc., 2018, 140, 17418-17422.

DOI: 10.1021/jacs.8b11390

see article for more reactions


An Ir-catalyzed enantioselective benzylation reaction of allylic electrophiles can occur directly from aryl acetic acids via stereoselective carbon-carbon bond formation followed by decarboxylation as the terminal event. The absence of a highly basic nucleophile enables broad functional group compatibility.

see article for more examples

Key Words

allylation, benzylation

ID: J48-Y2018