Synthesis of Isothiochroman-3-ones via Metal-Free Oxidative Cyclization of Alkynyl Thioethers
Ying-Qi Zhang, Xin-Qi Zhu, Yang-Bo Chen, Tong-De Tan, Ming-Yang Yang, Long-Wu Ye*
*College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China,
Email: longwuye
xmu.edu.cn
Y.-Q. Zhang, X.-Q. Zhu, Y.-B. Chen, T.-D. Tan, M.-Y. Yang, L.-W. Ye, Org. Lett., 2018, 20, 7721-7725.
DOI: 10.1021/acs.orglett.8b03462
see article for more reactions
Abstract
A Brønsted acid-catalyzed oxidative C-H functionalization of alkynyl thioethers provides valuable isothiochroman-3-ones in good yields under mild reaction conditions. This metal-free reaction offers a broad substrate scope and wide functional group tolerance.
see article for more examples
Key Words
benzo-fused S-Heterocycles, pyridine N-oxides
ID: J54-Y2018
