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Synthesis of Isothiochroman-3-ones via Metal-Free Oxidative Cyclization of Alkynyl Thioethers

Ying-Qi Zhang, Xin-Qi Zhu, Yang-Bo Chen, Tong-De Tan, Ming-Yang Yang, Long-Wu Ye*

*College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China, Email: longwuyexmu.edu.cn

Y.-Q. Zhang, X.-Q. Zhu, Y.-B. Chen, T.-D. Tan, M.-Y. Yang, L.-W. Ye, Org. Lett., 2018, 20, 7721-7725.

DOI: 10.1021/acs.orglett.8b03462 (free Supporting Information)


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Abstract

A Brønsted acid-catalyzed oxidative C-H functionalization of alkynyl thioethers provides valuable isothiochroman-3-ones in good yields under mild reaction conditions. This metal-free reaction offers a broad substrate scope and wide functional group tolerance.

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Key Words

benzo-fused S-Heterocycles, pyridine N-oxides


ID: J54-Y2018