Copper-Catalyzed Indole-Selective C-N Coupling Reaction of Indolyl(2-alkoxy-phenyl)iodonium Imides: Effect of Substituent on Iodoarene as Dummy Ligand
Kazuhiro Watanabe, Katsuhiko Moriyama*
*Department of Chemistry, Graduate School of Science, and Molecular Chirality Research Center, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan, Email: moriyamafaculty.chiba-u.jp
K. Watanabe, K. Moriyama, J. Org. Chem., 2018, 83, 14827-14833.
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A monoalkoxy phenyl group as a dummy ligand on indolyl(aryl)iodonium imides enables a copper-catalyzed indole-selective C-N coupling reaction to provide 3-bissulfonimido-indole derivatives in high yields. A one-pot synthesis of 3-bissulfonimido-indole derivatives directly from indoles, bissulfonimides, and (diacetoxyiodo)-2-butoxybenzene is also reported.
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