One-Pot Reaction of Carboxylic Acids and Ynol Ethers for The Synthesis of β-Keto Esters
Linwei Zeng, Zhencheng Lai, Sunliang Cui*
*Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China,
Email: slcui
zju.edu.cn
L. Zeng, Z. Lai, S. Cui, J. Org. Chem., 2018, 83, 14834-14841.
DOI: 10.1021/acs.joc.8b02715
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Abstract
An one-pot reaction of carboxylic acids and ynol ethers provides β-keto esters under promotion of Ag2O and a subsequent DMAP-catalyzed rearrangement. This protocol offers mild reaction conditions and a broad substrate scope.
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Decarbonylative Coupling of α-Keto Acids and Ynamides for Synthesis of β-Keto Imides
R. Chen, L. Zeng, B. Hoang, Y. Shen, S. Cui, Org. Lett., 2018, 20, 3377-3380.
Key Words
ID: J42-Y2018
