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One-Pot Reaction of Carboxylic Acids and Ynol Ethers for The Synthesis of β-Keto Esters

Linwei Zeng, Zhencheng Lai, Sunliang Cui*

*Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China, Email: slcuizju.edu.cn

L. Zeng, Z. Lai, S. Cui, J. Org. Chem., 2018, 83, 14834-14841.

DOI: 10.1021/acs.joc.8b02715 (free Supporting Information)



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Abstract

An one-pot reaction of carboxylic acids and ynol ethers provides β-keto esters under promotion of Ag2O and a subsequent DMAP-catalyzed rearrangement. This protocol offers mild reaction conditions and a broad substrate scope.

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Decarbonylative Coupling of α-Keto Acids and Ynamides for Synthesis of β-Keto Imides

R. Chen, L. Zeng, B. Hoang, Y. Shen, S. Cui, Org. Lett., 2018, 20, 3377-3380.


Key Words

β-Keto Esters


ID: J42-Y2018