Nickel-Catalyzed Cross-Electrophile Coupling between Benzyl Alcohols and Aryl Halides Assisted by Titanium Co-reductant

Takuya Suga*, Yutaka Ukaji*

*Division of Material Chemistry, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa, Ishikawa 920-1192, Japan, Email: suga-tse.kanazawa-u.ac.jp, ukajistaff.kanazawa-u.ac.jp

T. Suga, Y. Ukaji, Org. Lett., 2018, 20, 7846-7850.

DOI: 10.1021/acs.orglett.8b03367

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Abstract

A nickel-catalyzed cross-electrophile coupling reaction between benzyl alcohols and aryl halides is mediated by a low-valent titanium reagent generated from TiCl₄(2,6-lutidine) and manganese powder. The reaction afforded the cross-coupled product in high yield.

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Key Words

diarylmethanes. manganese, titanium

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ID: J54-Y2018