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Microwave-Assisted Nickel-Catalyzed Synthesis of Benzimidazoles: Ammonia as a Cheap and Nontoxic Nitrogen Source

Fang Ke*, Peng Zhang, Yiwen Xu, Xiaoyan Lin, Jin Lin, Chen Lin, Jianhua Xu

*College of Pharmacy, Fujian Medical University, Fuzhou 350004, P. R. of China, Email:

F. Ke, P. Zhang, Y. Xu, X. Lin, J. Lin, C. Lin, J. Xu, Synlett, 2018, 29, 2722-2726.

DOI: 10.1055/s-0037-1610843 (free Supporting Information)

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An efficient and convenient Ni-catalyzed C-N bond formation enables the synthesis of various benzimidazoles in excellent yields from various 2-haloanilines, aldehydes, and ammonia as nitrogen source.

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Key Words

nickel catalysis, C-N bond formation, benzimidazoles, microwave synthesis, ammonia

ID: J72-Y2018