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Synthesis of 2H-Azirines via Iodine-Mediated Oxidative Cyclization of Enamines

Manman Wang, Jiao Hou, Wenquan Yu*, Junbiao Chang*

*College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, Henan 450001, People's Republic of China, Email:,

M. Wang, J. Hou, W. Yu, J. Chang, J. Org. Chem., 2018, 83, 14954-14961.

DOI: 10.1021/acs.joc.8b02022

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A facile and practical oxidative cyclization reaction of enamines to 2H-azirines is mediated by molecular iodine under mild conditions. This transition metal-free approach provides 2H-azirine derivatives in an efficient and scalable fashion.

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Key Words

2H-Azirines, Iodine

ID: J42-Y2018