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Synthesis of 2-Quinolinones via a Hypervalent Iodine(III)-Mediated Intramolecular Decarboxylative Heck-Type Reaction at Room Temperature

Huaqiang Fan, Peng Pan, Yongqiang Zhang*, Wei Wang*

*East China University of Science and Technology, Shanghai 200237, P. R. China; University of Arizona, Tucson, Arizona 85721-0207, United States, Email:,

H. Fan, P. Pan, Y. Zhang, W. Wang, Org. Lett., 2018, 20, 7929-7932.

DOI: 10.1021/acs.orglett.8b03503

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A hypervalent iodine(III)-mediated intramolecular decarboxylative Heck-type reaction of 2-vinyl-phenyl oxamic acids provides various 2-quinolinones with excellent chemoselectivity at room temperature via a unique ring-strain-enabled radical decarboxylation mechanism. This protocol features metal-free reaction conditions and operational simplicity.

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Key Words

2-quinolones, hypervalent iodine compounds

ID: J54-Y2018