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Metal-Free Oxidative Thioesterification of Methyl Ketones with Thiols/Disulfides for the Synthesis of α-Ketothioesters

Biao Hu, Pan Zhou, Qiaohe Zhang, Yanqin Wang, Siyun Zhao, Lingling Lu, Shengjiao Yan*, Fuchao Yu*

*Yunnan University, Kunming 650091; Kunming University of Science and Technology, Kunming 650500, People's Republic of China, Email:,

B. Hu, Pan Zhou, Q. Zhang, Y. Wang, S. Zhao, L. Lu, S. Yan, F. Yu, J. Org. Chem., 2018, 83, 14978-14986.

DOI: 10.1021/acs.joc.8b02235

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A direct Csp3-H bond oxidative thioesterification of methyl ketones with aromatic thiols/disulfides is promoted by TBAI/K2S2O8 to provide functionalized α-ketothioesters. This efficient reaction offers large-scale applicability and broad functional group tolerance.

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Key Words

thioesterification, potassium peroxydisulfate

ID: J42-Y2018