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Phenolate Enabled General and Selective Fe/Ti Cocatalyzed Biaryl Cross-Couplings between Aryl Halides and Aryl Grignard Reagents

Rui Zhang, Yan Zhao, Kun-Ming Liu, Xin-Fang Duan*

*College of Chemistry, Beijing Normal University, Beijing 100875, China, Email:

R. Zhang, Y. Zhao, K.-M. Liu, X.-F. Duan, Org. Lett., 2018, 20, 7942-7946.

DOI: 10.1021/acs.orglett.8b03513

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Addition of a phenolate to FeCl3/Ti(OEt)4/TMEDA enables a strong Fe/Ti cooperativity that can efficiently catalyze a general and selective biaryl coupling reaction in the absence of ligands. Various aryl iodides, bromides, and chlorides can be coupled with a variety of common and Knochel-type aryl Grignard reagents. A wide range of sensitive functional groups in either coupling partner are tolerated.

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Key Words


ID: J54-Y2018