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Highly Active Platinum Catalysts for Nitrile and Cyanohydrin Hydration: Catalyst Design and Ligand Screening via High-Throughput Techniques

Xiangyou Xing, Chen Xu, Bo Chen, Chengcheng Li, Scott C. Virgil*, Robert H. Grubbs*

*The Warren and Katharine Schlinger Laboratory, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States, Email:,

X. Xing, C. Xu, B. Chen, C. Li, S. C. Virgil, R. H. Grubbs, J. Am. Chem. Soc., 2018, 140, 17782-17789.

DOI: 10.1021/jacs.8b11667

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The enhanced activity of a "donor-acceptor"-type catalyst, which is readily prepared from (DPPF)PtCl2, PMe2OH, and AgOTf, permits the hydration of a wide range of nitriles and cyanohydrins to proceed at 40C with excellent turnover numbers.

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Key Words


ID: J48-Y2018