Photochemical Preparation of 1,2-Dihydro-3H-indazol-3-ones in Aqueous Solvent at Room Temperature
Jie S. Zhu, Niklas Kraemer, Clarabella J. Li, Makhluf J. Haddadin, Mark J. Kurth*
*Department of Chemistry, University of California Davis, 1 Shields Avenue, Davis, California 95616, United States, Email: mjkurthucdavis.edu
J. S. Zhu, N. Kraemer, C. J. Li, M. J. Haddadin, M. J. Kurth, J. Org. Chem., 2018, 83, 15493-15498.
DOI: 10.1021/acs.joc.8b02356
Abstract
o-Nitrosobenzaldehyde is a useful reactive intermediate for the synthesis of nitrogen heterocycles. This intermediate can be photochemically generated in situ from o-nitrobenzyl alcohols in an efficient manner for the construction of 1,2-dihydro-3H-indazol-3-ones using an aqueous solvent at room temperature.
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J. S. Zhu, N. Kraemer, M. E. Shatskikh, C. J. Li, J.-H. Son, M. H. Haddadin, D. J. Tantillo, M. J. Kurth, Org. Lett., 2018, 20, 4736-4739.
Key Words
indazolones, photochemistry
ID: J42-Y2018