Organic Chemistry Portal



Rhodium-Catalyzed Tandem Reaction of Isocyanides with Azides and Oxygen Nucleophiles: Synthesis of Isoureas

Xiu-Bin Bu, Zhi-Xin Zhang, Qin-Qin Peng, Xianxiu Xu, Yu-Long Zhao*

*Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China, Email:

X.-B. Bu, Z.-X. Zhang, Q.-Q. Peng, X. Xu, Y.-L. Zhao, J. Org. Chem., 2019, 84, 53-59.

DOI: 10.1021/acs.joc.8b01503

see article for more reactions


A highly efficient rhodium-catalyzed tandem reaction of isocyanides with azides and various oxygen nucleophiles provides various N-sulfonyl/acylisoureas with broad substrate scope in an atom-economical manner.

see article for more examples

Key Words

Isoureas (C=N, C-O), Multicomponent Reactions

ID: J42-Y2019