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Rhodium-Catalyzed Tandem Reaction of Isocyanides with Azides and Oxygen Nucleophiles: Synthesis of Isoureas

Xiu-Bin Bu, Zhi-Xin Zhang, Qin-Qin Peng, Xianxiu Xu, Yu-Long Zhao*

*Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China, Email: zhaoyl351nenu.edu.cn

X.-B. Bu, Z.-X. Zhang, Q.-Q. Peng, X. Xu, Y.-L. Zhao, J. Org. Chem., 2019, 84, 53-59.

DOI: 10.1021/acs.joc.8b01503



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Abstract

A highly efficient rhodium-catalyzed tandem reaction of isocyanides with azides and various oxygen nucleophiles provides various N-sulfonyl/acylisoureas with broad substrate scope in an atom-economical manner.

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Key Words

Isoureas (C=N, C-O), Multicomponent Reactions


ID: J42-Y2019