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Pd/PTABS: Catalyst for Room Temperature Amination of Heteroarenes

Siva Sankar Murthy Bandaru, Shatrughn Bhilare, Nicolas Chrysochos, Vijay Gayakhe, Ivan Trentin, Carola Schulzke, Anant R. Kapdi*

*Department of Chemistry, Institute of Chemical Technology, Nathalal Road, Matunga, Mumbai 400019, India, Email:

S. S. M. Bandaru, S. Bhilare, N. Chrysochos, V. Gayakhe, I. Trentin, C. Schulzke, A. R. Kapdi, Org. Lett., 2018, 20, 473-476.

DOI: 10.1021/acs.orglett.7b03854 (free Supporting Information)

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The combination of Pd/PTABS enables an exceptionally mild and highly efficient catalytic amination of chloroheteroarenes with secondary amines at ambient temperature.

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Key Words

Buchwald-Hartwig coupling, pyrazines, quinoxalines, benzoxazoles

ID: J54-Y2018