Iron-Catalyzed Radical Acyl-Azidation of Alkenes with Aldehydes: Synthesis of Unsymmetrical β-Azido Ketones
Liang Ge, Yajun Li, Hongli Bao*
*Chinese Academy of Sciences, 155 Yangqiao Road West, Fuzhou, Fujian 350002, People’s Republic of China, Email: hlbaofjirsm.ac.cn
L. Ge, Y. Li, H. Bao, Org. Lett., 2019, 21, 256-260.
see article for more reactions
An iron-catalyzed acyl-azidation of alkenes provides unsymmetrical β-azido ketones under mild reaction conditions from aromatic aldehydes or aliphatic aldehydes as the acyl radical precursors, TMSN3 as the azido source, and TBHP as the initiator. The synthesized unsymmetrical β-azido ketones can be easily transformed into valuable functionalized compounds.
see article for more examples