Organic Chemistry Portal

Abstracts

Search:

Ph3P/I--Promoted Dichlorination or Dibromination of Epoxides with XCH2CH2X (X = Cl or Br)

Jin Long, Jia Chen, Rong Li, Zhuo Liu, Xuan Xiao, Jin-Hong Lin*, Xing Zheng*, Ji-Chang Xiao*

*Shanghai Institute of Organic Chemistry, 345 Lingling Road, Shanghai 200032; University of South China, Hengyang, Hunan, 421001, P. R. of China, Email: jlinsioc.ac.cn, zhengxing5018yahoo.com, jchxiaosioc.ac.cn

J. Long, J. Chen, R. Li, Z. Liu, X. Xiao, J.-H. Ling, X. Zheng, J.-C. Xiao, Synlett, 2019, 30, 181-184.

DOI: 10.1055/s-0037-1610308 (free Supporting Information)


see article for more reactions

Abstract

A Ph3P/I--promoted dihalogenation of epoxides provides 1,2-dihalides in the presence of XCH2CH2X (X = Cl or Br) as the solvent and halogen source. All reagents are widely available and easy to handle. The protocol offers mild conditions and operational simplicity.

see article for more examples



Key Words

epoxides, dichlorination, dibromination, 1,2-dihalides, triphenylphosphine


ID: J72-Y2019