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Hydrosilane Reduction of Nitriles to Primary Amines by Cobalt-Isocyanide Catalysts

Atsushi Sanagawa, Hideo Nagashima*

*Institute for Materials Chemistry and Engineering, Kyushu University, Kasuga, Fukuoka 816-8580, Japan, Email: nagasimacm.kyushu-u.ac.jp

A. Sanagawa, H. Nagashima, Org. Lett., 2019, 21, 287-291.

DOI: 10.1021/acs.orglett.8b03736 (free Supporting Information)


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Abstract

The conversion of nitriles to silylated primary amines was achieved in the presence of TMDS as the reducing agent, a catalytic amount of Co(OPiv)2, and an isocyanide ligand. Acid hydrolysis or treatment with acid chlorides provided the corresponding primary amines or imides in good yields.


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Key Words

reduction of nitriles, TMDS


ID: J54-Y2019