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Catalytic Transfer Hydration of Cyanohydrins to α-Hydroxyamides

Tomoya Kanda, Asuka Naraoka, Hiroshi Naka*

*Research Center for Materials Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan, Email:

T. Kanda, A. Naraoka, H. Naka, J. Am. Chem. Soc., 2019, 141, 825-830.

DOI: 10.1021/jacs.8b12877

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A palladium(II)-catalyzed transfer hydration of various aldehyde- and ketone-derived cyanohydrins provides α-mono- and α,α-disubstituted-α-hydroxyamides by using carboxamides as water donors under mild conditions.

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proposed mechanism

Key Words


ID: J48-Y2019