A General Protocol for the Synthesis of H-α-Hydroxyphosphinates
Jade Dussart, Julia Deschamp*, Maelle Monteil, Olivier Gager, Evelyne Migianu-Griffoni, Marc Lecouvey*
*Université Paris 13, Sorbonne Paris Cité, Laboratoire CSPBAT, CNRS UMR 7244, 93017 Bobigny Cedex, France,
Email: julia.deschamp
univ-paris13.fr, marc.lecouveyuniv-paris13.fr
J. Dussart, J. Deschamp, M. Monteil, O. Gager, E. Migianu-Griffoni, M. Lecouvey, Synthesis, 2019, 51, 421-432.
DOI: 10.1055/s-0037-1610274
Abstract
A general synthetic procedure using 2 eq. of BSA as silylating agent provides H-α-hydroxyphosphinates in very good yields in short times via Abramov reaction. The H-α-hydroxyphosphinates can easily be purified and obtained.
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Key Words
α-hydroxyphosphinates, synthetic methods, phosphorus, phosphonylation, H-phosphinates
ID: J66-Y2019
