Synthesis of α-Keto Thioamides by Metal-Free C=C Bond Cleavage in Enaminones Using Elemental Sulfur
Lu Gan, Yong Gao, Li Wei, Jie-Ping Wan*
*College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P. R. China, Email: wanjiepingjxnu.edu.cn
L. Gan, Y. Gao, L. Wei, J.-P. Wan, J. Org. Chem., 2019, 84, 1064-1069.
DOI: 10.1021/acs.joc.8b02670
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Abstract
A cleavage of the C=C bond in N,N-disubstituted enaminones in the presence of elemental sulfur and DMAP provides N,N-disubstituted α-keto thioamides without using any metal catalyst or additive.
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proposed mechanism
Key Words
ID: J42-Y2019