An Improved N-Acylation of 1H-Benzotriazole Using 2,2′-Dipyridyl­di­sulfide and Triphenylphosphine

Anoop S. Singh, Anand K. Agrahari, Nidhi Mishra, Mala Singh, Vinod K. Tiwari*

*Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, India, Email: vinod.tiwaribhu.ac.in

A. S. Singh, A. K. Agrahari, N. Mishra, M. Singh, V. K. Tiwari, Synthesis, 2019, 51, 470-476.

DOI: 10.1055/s-0037-1610277

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Abstract

The combination of 2,2′-dipyridyl disulfide and PPh₃ enables the conversion of carboxylic acids into the corresponding N-acylbenzotriazoles in the presence of 1H-benzotriazole. This base-free reaction offers mild conditions, short reaction time, and wide substrate scope.

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Trichloroisocyanuric Acid Mediated High-Yielding Synthesis of N-Acylbenzotriazoles under Mild Reaction Conditions

M. Singh, A. S. Singh, N. Mishra, A. K. Agrahari, V. K. Tiwari, Synthesis, 2019, 51, 2183-2190.

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Key Words

N-acylbenzotriazoles, benzotriazoles, coupling reactions, acylation, PPh₃, PySSPy

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ID: J66-Y2019