Urea-Zinc Chloride Eutectic Mixture-Mediated One-Pot Synthesis of Imidazoles: Efficient and Ecofriendly Access to Trifenagrel
Natalia López Higuera, Diana Peña-Solórzano, Cristian Ochoa-Puentes*
*Laboratorio de Síntesis Orgánica Sostenible, Departamento de Química, Universidad Nacional de Colombia-Sede Bogotá, Carrera 45 # 26-85, A.A 5997, Bogotá, Colombia, Email: cochoapuunal.edu.co
N. L. Higuera, D. Peña-Solórzano, C. Ochoa-Puentes, Synlett, 2019, 30, 225-229.
DOI: 10.1055/s-0037-1610679
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Abstract
The low-melting mixture urea-ZnCl2 as reaction medium efficiently catalyzes the reaction of a dicarbonyl compound, ammonium acetate, and an aromatic aldehyde to provide a broad range of triaryl-1H-imidazoles or 2-aryl-1H-phenanthro[9,10-d]imidazoles in very good yields. In addition, the eutectic solvent can be reused five times without loss of catalytic activity.
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Key Words
imidazoles, deep eutectic solvents, multicomponent reactions, trifenagrel, phenanthroimidazoles
ID: J72-Y2019