Nickel-Catalyzed Addition of Aryl Bromides to Aldehydes To Form Hindered Secondary Alcohols
Kevin J. Garcia, Michael M. Gilbert, Daniel J. Weix*
*Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States, Email: dweixwisc.edu
K. J. Garcia, M. M. Gilbert, D. J. Weix, J. Am. Chem. Soc., 2019, 141, 1823-1827.
DOI: 10.1021/jacs.8b13709 (free Supporting Information)
see article for more reactions
Simple nickel complexes of bipyridine and PyBox catalyze the addition of aryl halides to both aromatic and aliphatic aldehydes using zinc metal as the reducing agent. This convenient approach tolerates acidic functional groups that are not compatible with Grignard reactions, yet sterically hindered substrates still couple in high yield.
see article for more examples