Enantioselective Ir-Catalyzed Allylic Alkylation of Racemic Allylic Alcohols with Malonates

Chun-Yan Meng, Xiao Liang, Kun Wei*, Yu-Rong Yang*

*State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China, Email: weikunmail.kib.ac.cn, yangyurongmail.kib.ac.cn

C.-Y. Meng, X. Liang, K. Wei, Y.-R. Yang, Org. Lett., 2019, 21, 840-843.

DOI: 10.1021/acs.orglett.8b04143

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Abstract

Carreira's chiral Ir/(P, olefin) complex enables an enantioselective allylic alkylation of branched racemic allylic alcohols with malonates with excellent enantioselectivity. The malonates could be used directly as efficient nucleophiles without the need for preactivation.

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Key Words

allylation, benzylation

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ID: J54-Y2019