Enantioselective Ir-Catalyzed Allylic Alkylation of Racemic Allylic Alcohols with Malonates
Chun-Yan Meng, Xiao Liang, Kun Wei*, Yu-Rong Yang*
*State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China, Email: weikunmail.kib.ac.cn, yangyurongmail.kib.ac.cn
C.-Y. Meng, X. Liang, K. Wei, Y.-R. Yang, Org. Lett., 2019, 21, 840-843.
DOI: 10.1021/acs.orglett.8b04143 (free Supporting Information)
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Carreira's chiral Ir/(P, olefin) complex enables an enantioselective allylic alkylation of branched racemic allylic alcohols with malonates with excellent enantioselectivity. The malonates could be used directly as efficient nucleophiles without the need for preactivation.
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