Palladium-Catalyzed Carbonylative Synthesis of Isoindolinones from Benzylamines with TFBen as the CO Source
Lu-Yang Fu, Jun Ying*, Xinxin Qi, Jin-Bao Peng, Xiao-Feng Wu*
*Department of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou 310018, People's Republic of China, Email: yingjunzstu.edu.cn, xiao-feng.wucatalysis.de
L-Y. Fu, J. Ying, X. Qi, J.-B. Peng, X.-F. Wu, J. Org. Chem., 2019, 84, 1238-1246.
DOI: 10.1021/acs.joc.8b02862 (free Supporting Information)
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A palladium-catalyzed C-H carbonylation of benzylamines provides isoindolinone scaffolds in good yields under gas-free conditions by using benzene-1,3,5-triyl triformate (TFBen) as a convenient CO surrogate.
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