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Fukuyama Cross-Coupling Approach to Isoprekinamycin: Discovery of the Highly Active and Bench-Stable Palladium Precatalyst POxAP

Shuang-Qi Tang, Jacques Bricard, Martine Schmitt, Frédéric Bihel*

*Laboratoire d’Innovation Thérapeutique, Labex MEDALIS, Faculté de Pharmacie, UMR7200 CNRS, Université de Strasbourg, 74 Route du Rhin, 67412 Illkirch, France, Email:

S.-Q. Tang, J. Bricard, M. Schmitt, F. Bihel, Org. Lett., 2019, 21, 844-848.

DOI: 10.1021/acs.orglett.9b00031 (free Supporting Information)

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An air stable palladium(II) precatalyst catalyzes Fukuyama cross-coupling reactions between thioesters and organozinc reagents with high turnover numbers. A series of 23 ketones were obtained with good yields.

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Key Words

Fukuyama Coupling

ID: J54-Y2019