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Aza-Rubottom Oxidation: Synthetic Access to Primary α-Aminoketones

Zhe Zhou, Qing-Qing Cheng, László Kürti*

*Department of Chemistry, Rice University BioScience Research Collaborative, 6500 Main Street, Houston, Texas 77030, United States, Email:

Z. Zhou, Q.-Q. Cheng, L. Kürti, J. Am. Chem. Soc., 2019, 141, 2242-2246.

DOI: 10.1021/jacs.8b13818

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An aza analogue of the Rubottom oxidation of silyl enol ethers takes place at ambient temperature and provides primary α-aminoketones. The use of hexafluoroisopropanol (HFIP) as the solvent is crucial for the success of this facile aza-functionalization reaction.

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Key Words

Rubottom Oxidation, α-Amino Ketones

ID: J48-Y2019