An Effective [FeIII(TF4DMAP)Cl] Catalyst for C-H Bond Amination with Aryl and Alkyl Azides
Yi-Dan Du, Zhen-Jiang Xu, Cong-Ying Zhou, Chi-Ming Che*
*State Key Laboratory of Synthetic Chemistry and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China, Email: cmchehku.hk
Y.-D. Du, Z.-J. Xu, C.-Y. Zhou, C.-M. Che, Org. Lett., 2019, 21, 895-899.
DOI: 10.1021/acs.orglett.8b03765 (free Supporting Information)
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[FeIII(TF4DMAP)Cl] efficiently catalyzes an intermolecular sp3 C-H amination using aryl azides and intramolecular sp3 C-H amination of alkyl azides in good yields. The reaction offers high chemo- and regioselectivity with broad substrate scope and can be used for late-stage functionalization of complex natural/bioactive molecules.
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