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Selective Hydroboration of Carboxylic Acids with a Homogeneous Manganese Catalyst

Milan K. Barman, Kuhali Das, Biplab Maji*

*Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, India, Email: bmiiserkol.ac.in

M. K. Barman, K. Das, B. Maji, J. Org. Chem., 2019, 84, 1570-1579.

DOI: 10.1021/acs.joc.8b03108 (free Supporting Information)



Abstract

A manganese-catalyzed chemoselective hydroboration of carboxylic acids to the corresponding alcohols offers a high turnover number and turnover frequency at 25C. This method tolerates electronically and sterically differentiated substrates with high chemoselectivity. Importantly, aliphatic long-chain fatty acids, including biomass-derived compounds, can efficiently be reduced.

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Key Words

reduction of carboxylic acids, pinacolborane


ID: J42-Y2019