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One-Pot, Multistep Reactions for the Modular Synthesis of N,N'-Diarylindazol-3-ones

Shuai Liu, Liang Xu, Yu Wei*

*School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832003, China, Email: yuweichemshzu.edu.cn

S. Liu, L. Xu, Y. Wei, J. Org. Chem., 2019, 84, 1596-1604.

DOI: 10.1021/acs.joc.8b02548 (free Supporting Information)


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Abstract

A Cu-catalyzed oxidative C-N cross-coupling and dehydrogenative N-N formation sequence of readily available isatoic anhydrides, aryl amines, and aryl boronic acids under an air atmosphere affords indazol-3-one derivatives in good to excellent yields.

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Key Words

Chan-Lam coupling, indazolones


ID: J42-Y2019