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Asymmetric Borylative Propargylation of Ketones Catalyzed by a Copper(I) Complex

Xu-Cheng Gan, Liang Yin*

*Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China, Email: liangyinsioc.ac.cn

X.-C. Gan, L. Yin, Org. Lett., 2019, 21, 931-936.

DOI: 10.1021/acs.orglett.8b03912 (free Supporting Information)


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Abstract

A copper(I)-catalyzed asymmetric borylative propargylation of simple ketones offers broad substrate scope, good tolerance of functional groups, high diastereo- and enantioselectivities, and reaction robustness. The borylative product can also serve as a cross-coupling partner in Pd-catalyzed Suzuki-Miyaura reactions.


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Key Words

1,3-diols, homopropargylic alcohols, sodium perborate


ID: J54-Y2019