Asymmetric Borylative Propargylation of Ketones Catalyzed by a Copper(I) Complex
Xu-Cheng Gan, Liang Yin*
*Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China, Email: liangyinsioc.ac.cn
X.-C. Gan, L. Yin, Org. Lett., 2019, 21, 931-936.
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A copper(I)-catalyzed asymmetric borylative propargylation of simple ketones offers broad substrate scope, good tolerance of functional groups, high diastereo- and enantioselectivities, and reaction robustness. The borylative product can also serve as a cross-coupling partner in Pd-catalyzed Suzuki-Miyaura reactions.
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1,3-diols, homopropargylic alcohols, sodium perborate