Organic Chemistry Portal

Abstracts

Search:

Ir-Catalyzed Intermolecular Branch-Selective Allylic C-H Amidation of Unactivated Terminal Olefins

Honghui Lei, Tomislav Rovis*

*Department of Chemistry, Columbia University, New York, New York 10027, United States, Email: tr2504columbia.edu

H. Lei, T. Rovis, J. Am. Chem. Soc., 2019, 141, 2268-2273.

DOI: 10.1021/jacs.9b00237 (free Supporting Information)



see article for more reactions

Abstract

Ir(III) catalysis enables an efficient intermolecular branch-selective allylic C-H amidation in good yields and regioselectivities. The reaction proceeds through initial allylic C-H activation followed by a subsequent oxidative amidation with readily available dioxazolones as nitrenoid precursors.

see article for more examples



Key Words

allylic amines, amidation


ID: J48-Y2019