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Ir-Catalyzed Intermolecular Branch-Selective Allylic C-H Amidation of Unactivated Terminal Olefins

Honghui Lei, Tomislav Rovis*

*Department of Chemistry, Columbia University, New York, New York 10027, United States, Email:

H. Lei, T. Rovis, J. Am. Chem. Soc., 2019, 141, 2268-2273.

DOI: 10.1021/jacs.9b00237

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Ir(III) catalysis enables an efficient intermolecular branch-selective allylic C-H amidation in good yields and regioselectivities. The reaction proceeds through initial allylic C-H activation followed by a subsequent oxidative amidation with readily available dioxazolones as nitrenoid precursors.

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Key Words

allylic amines, amidation

ID: J48-Y2019