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Catalyst-Free Annulation of 2-Pyridylacetates and Ynals with Molecular Oxygen: An Access to 3-Acylated Indolizines

Zhengwang Chen*, Pei Liang, Xiaoyue Ma, Haiqing Luo, Guohai Xu, Tanggao Liu, Xiaowei Wen, Jing Zheng, Hui Ye*

*Hubei Key Laboratory of Processing and Application of Catalytic Materials, Huanggang Normal University, Huanggang, 438000, China, Email:

Z. Chen, P. Liang, X. Ma, H. Luo, G. Xu, T. Liu, X. Wen, J. Zheng, H. Ye, J. Org. Chem., 2019, 84, 1630-1639.

DOI: 10.1021/acs.joc.8b02883

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A catalyst and additive-free annulation of 2-pyridylacetates and ynals provides 3-acylated indolizines in very good yields under molecular oxygen. This approach tolerates a wide range of functional groups.

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Key Words

indolizines, oxygen

ID: J42-Y2019