Catalyst-Free, Metal-Free, and Chemoselective Transamidation of Activated Secondary Amides
Rajagopal Ramkumar, Srinivasan Chandrasekaran*
*Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India,
Email: scn
iisc.ac.in
R. Ramkumar, S. Chandrasekaran, Synthesis, 2019, 51, 921-932.
Abstract
A simple catalyst- and metal-free protocol enables a chemoselective transamidation of activated secondary amides in ethanol as solvent under mild conditions. A wide range of amines, amino acids, amino alcohols are tolerated in this methodology. The transamidation reaction was successfully extended to water as the medium as well.
see article for more examples
Key Words
amino acid, catalyst-free, metal-free, chemoselective, amides, transamidation
ID: J66-Y2019
