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Catalyst-Free, Metal-Free, and Chemoselective Transamidation of Activated Secondary Amides

Rajagopal Ramkumar, Srinivasan Chandrasekaran*

*Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India, Email: scniisc.ac.in

R. Ramkumar, S. Chandrasekaran, Synthesis, 2019, 51, 921-932.

DOI: 10.1055/s-0037-1610664 (free Supporting Information)


Abstract

A simple catalyst- and metal-free protocol enables a chemoselective transamidation of activated secondary amides in ethanol as solvent under mild conditions. A wide range of amines, amino acids, amino alcohols are tolerated in this methodology. The transamidation reaction was successfully extended to water as the medium as well.


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Key Words

amino acid, catalyst-free, metal-free, chemoselective, amides, transamidation


ID: J66-Y2019