Organic Chemistry Portal



Alkenyl Exchange of Allylamines via Nickel(0)-Catalyzed C-C Bond Cleavage

Chao Fan, Xin-Yang Lv, Li-Jun Xiao*, Jian-Hua Xie, Qi-Lin Zhou*

*College of Chemistry, Nankai University, Tianjin 300071, China, Email:,

C. Fan, X.-Y. Lv, L.-J. Xiao, J.-H. Xie, Q.-L. Zhou, J. Am. Chem. Soc., 2019, 141, 2889-2893.

DOI: 10.1021/jacs.8b13251 (free Supporting Information)

see article for more reactions


Nickel-catalyzed C-C bond cleavage and formation enables a functional group exchange reaction between allylamines and alkenes to provide allylamines, which are widely used in the production of pharmaceuticals, agrochemicals, and fine chemicals.

see article for more examples

proposed mechanism

Key Words

allylic amines

ID: J48-Y2019