Organic Chemistry Portal

Abstracts

Search:

Alkenyl Exchange of Allylamines via Nickel(0)-Catalyzed C-C Bond Cleavage

Chao Fan, Xin-Yang Lv, Li-Jun Xiao*, Jian-Hua Xie, Qi-Lin Zhou*

*College of Chemistry, Nankai University, Tianjin 300071, China, Email: 1120140207mail.nankai.edu.cn, qlzhounankai.edu.cn

C. Fan, X.-Y. Lv, L.-J. Xiao, J.-H. Xie, Q.-L. Zhou, J. Am. Chem. Soc., 2019, 141, 2889-2893.

DOI: 10.1021/jacs.8b13251



see article for more reactions

Abstract

Nickel-catalyzed C-C bond cleavage and formation enables a functional group exchange reaction between allylamines and alkenes to provide allylamines, which are widely used in the production of pharmaceuticals, agrochemicals, and fine chemicals.

see article for more examples


proposed mechanism



Key Words

allylic amines


ID: J48-Y2019